IndraLab

Statements

COPS6 leads to the ubiquitination of MYC. 3 / 3
| 3
reach
"In mouse experiments, COPS6 was determined to increase tumor growth by decreasing the ubiquitination of Myc and enhancing the degradation of Fbxw7."
38576589
reach
"Because Myc is degraded through the ubiquitin pathway 38, we examined whether ubiquitination is involved and found that CSN6 overexpression inhibited Myc ubiquitination while shRNA-CSN6 increased Myc ubiquitination (XREF_FIG)."
25395170
reach
"Furthermore, Fbxw7 deficiency compromised CSN6 shRNA enhanced Myc ubiquitination (XREF_FIG), suggesting that CSN6 mediated Myc stabilization is dependent on Fbxw7."
25395170