IndraLab

Statements


OTUB1 activates KRAS. 3 / 3
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"Whereas down-regulation or loss of function of RABEX5 in human cancers has not been reported, we found that OTUB1 expression is commonly up-regulated in a substantial subset of NSCLCs harboring wt KRAS."

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"Taken together, these results suggest that an increase in OTUB1 expression accelerated tumorigenic transformation of wt KRAS NSCLCs."

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"OTUB1 has been reported to enhance membrane localization and promote the activation of wild-type KRAS—but not KRAS mutants—by suppressing the enzymatic activity of E2 enzymes ubiquitin-conjugating enzyme 13 (UBC13) and ubiquitin-conjugating enzyme E2 D3 (UBE2D3), indicating that OTUB1 regulates wild-type KRAS in an indirect manner ."