IndraLab

Statements

USP44 inhibits autophagy. 3 / 3
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"Moreover, downregulation of USP44 encoding gene blocks the induction of autophagy in mESCs (mouse embryonic stem cells) (XREF_FIG H)."
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"Mechanistically, linc-RA1 stabilized the level of H2B K120 monoubiquitination (H2Bub1) by combining with H2B and inhibiting the interaction between H2Bub1 and ubiquitin specific protease 44 (USP44), which inhibited autophagy, thus contributing to glioma radioresistance."
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"Knockdown of Usp44 results in the maintenance of H2Bub1 upon starvation and abolishes the change in expression of starvation induced autophagy related genes."
30126257