IndraLab

Statements

USP28 activates SOX9. 4 / 4
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"Collectively, our results revealed that USP28 prevents SOX9 proteasomal degradation by eliminating K48-linked polyubiquitin chains."
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"Knockdown of USP28 reduced the binding of SOX9 to the promoter regions of SMARCA4, UIMC1, and SLX4 (Fig. S9A)."
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"Additionally, USP28 promoted olaparib resistance by stabilizing SOX9 protein and enhancing DNA damage repair."
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"Furthermore, the USP28 specific inhibitor AZ1 reduced SOX9 protein stability and increased the sensitivity of ovarian cancer cells to olaparib."
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