IndraLab

Statements

ATP inhibits CHUK. 6 / 6
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"Instead, we found that PP2A knockdown abolished ATP mediated IKKalpha inhibition (XREF_SUPPLEMENTARY) suggesting that PP2A plays a direct role in inhibiting IKKalpha in response to signal 2 of NLRP3 activation."
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"In addition, the inhibition of IKKalpha kinase activity by ATP was not secondary to caspase-1-dependent cell death, as pre-treatment with the caspase-1 inhibitor zYVAD did not prevent ATP mediated IKKalpha inhibition (XREF_SUPPLEMENTARY)."
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"ATP inhibits IKKalpha and releases ASC."
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"Furthermore, to determine whether ATP signaling was sufficient to inhibit the activity of activated IKKalpha, we performed in vitro kinase assay using LPS primed macrophages treated with ATP."
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"We therefore speculated that PP2A might play a role in ATP mediated IKKalpha inhibition."
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"Moreover, ATP mediated IKKalpha inhibition was completely abolished in P2X7R -/- BMDMs (XREF_SUPPLEMENTARY)."
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