IndraLab

Statements

USP8 increases the amount of BACE1. 3 / 3
2 | 1
reach
"RNAi-mediated inhibition of USP8 decreases BACE1 expression in the H4 human neuroglioma cell line."
34023421
signor
"Here, we report that RNAi-mediated depletion of USP8 reduced levels of both ectopically expressed and endogenous BACE1 in H4 human neuroglioma cells. Moreover, USP8 depletion increased BACE1 ubiquitination, promoted BACE1 accumulation in the early endosomes and late endosomes/lysosomes, and decreased levels of BACE1 in the recycling endosomes."
27302062
signor
"Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501."
27302062