IndraLab

Statements

LS3 activates KCNMA1. 5 / 5
| 5
reach
"The LS3 induced slowing response was rescued in the slo-1 (null) background by transgenic expression of the wild-type slo-1 gene (XREF_FIG, XREF_SUPPLEMENTARY)."
28195225
reach
"Because the human BKalpha channel (HSLO) was used to select LS3, we hypothesized that LS3 would also modulate HSLO function."
28195225
reach
"The findings suggest that local BK channel modulation by LS3 enhances sound-evoked activity in aged mice and even generates de novo receptive fields in many dorsal IC neurons."
34861480
reach
"These other variations in channel composition could also lead to differential sensitivity and responses to BK channel manipulation by LS3 in the cochlea and IC XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
28195225
reach
"To determine whether LS3 modulates BK channel function in vivo with minimal off-target effects, we employed a Caenorhabditis elegans behavioral assay."
28195225