IndraLab

Statements

PLD2 activates KCNK2. 8 / 9
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"These data, combined with previous studies of PLD2 activation of TREK-1, led us to propose a model where PIP 2 can directly antagonize TREK-1."
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"These data, combined with previous studies of PLD2 activation of TREK-1 ( xref ), led us to propose a model where PIP 2 can directly antagonize TREK-1."
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"Even though all three of the channels are sensitive to PA, we found that only TREK1 and TREK2 are potentiated by PLD2 and that none of these channels is modulated by PLD1, indicating surprising selectivity."
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"For PLD2 dependent TREK-1 activation."
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"The threshold for PLD2-dependent TREK-1 activation proved to be quite sensitive."
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"In the other hand, the inside-out experiments showed that PUFAs activation occured independently of scaffold proteins like PLD2 known to modulate TREK-1 activity in response to disruption of lipid rafts ."
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"But PIP 2 also localizes PLD2 near TREK-1 which indirectly activates TREK-1."
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"For instance, PIP is known to activate PLD2 (Bowling et al., 2020), which would indirectly activate TREK-1 through PA or PG production."
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