IndraLab

Statements


PLD2 activates KCNK2. 7 / 8
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reach
"But PIP 2 also localizes PLD2 near TREK-1 which indirectly activates TREK-1."

reach
"PLD2 activates TREK-1 by binding to a disordered C terminus and producing high local concentrations of PA that activate the channel-the PLD1 isoenzyme does not activate the channel (29) ."

sparser
"PLD2 activates TREK-1 by binding to a disordered C terminus and producing high local concentrations of PA that activate the channel-the PLD1 isoenzyme does not activate the channel (29) ."

sparser
"These data, combined with previous studies of PLD2 activation of TREK-1 ( xref ), led us to propose a model where PIP 2 can directly antagonize TREK-1."

reach
"Even though all three of the channels are sensitive to PA, we found that only TREK1 and TREK2 are potentiated by PLD2 and that none of these channels is modulated by PLD1, indicating surprising selectivity."

reach
"These data, combined with previous studies of PLD2 activation of TREK-1, led us to propose a model where PIP 2 can directly antagonize TREK-1."

eidos
"PLD2 activates TREK-1 by binding to a disordered C terminus and producing high local concentrations of PA that activate the channel-the PLD1 isoenzyme does not activate the channel ( 29 ) ."