IndraLab

Statements

TNFAIP3 inhibits IRF3. 5 / 5
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"This gene is expressed as the A20/tumor necrosis factor α-induced protein 3 (TNFAIP3) protein, a ubiquitin ligase and deubiquitinating enzyme that inhibits nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF-3) activation to regulate innate immune responses ."
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eidos
"TNFAIP3 downregulates the activity of IRF-3 , a key transcription factor for the induction of IFN-gamma [ 36 ] ."
| PMC
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"XREF_BIBR Also, IRF3 dependent signaling is negatively regulated by TAX1BP1 and TNFAIP3."
28820283
eidos
"It was established that A20 is able to suppress IRF3 activation conducting to the reduction of the IFN-mediated immune response ( 44 ) ."
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"TNFAIP3 downregulates the activity of IRF-3, a key transcription factor for the induction of IFN-gamma [XREF_BIBR]."
| PMC