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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 inhibits IRF3. 4 / 4

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"TNFAIP3 downregulates the activity of IRF-3, a key transcription factor for the induction of IFN-gamma [XREF_BIBR]."

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"TNFAIP3 downregulates the activity of IRF-3 , a key transcription factor for the induction of IFN-gamma [ 36 ] ."

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"XREF_BIBR Also, IRF3 dependent signaling is negatively regulated by TAX1BP1 and TNFAIP3."

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"It was established that A20 is able to suppress IRF3 activation conducting to the reduction of the IFN-mediated immune response ( 44 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...