IndraLab

Statements

TNFAIP3 inhibits IRF3. 5 / 5
| 2 3
reach
"XREF_BIBR Also, IRF3 dependent signaling is negatively regulated by TAX1BP1 and TNFAIP3."
28820283
reach
"This gene is expressed as the A20/tumor necrosis factor α-induced protein 3 (TNFAIP3) protein, a ubiquitin ligase and deubiquitinating enzyme that inhibits nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF-3) activation to regulate innate immune responses ."
37679460
eidos
"TNFAIP3 downregulates the activity of IRF-3 , a key transcription factor for the induction of IFN-gamma [ 36 ] ."
| PMC
eidos
"It was established that A20 is able to suppress IRF3 activation conducting to the reduction of the IFN-mediated immune response ( 44 ) ."
30319634
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"TNFAIP3 downregulates the activity of IRF-3, a key transcription factor for the induction of IFN-gamma [XREF_BIBR]."
| PMC