IndraLab

Statements

OTUD3 inhibits Endoplasmic Reticulum Stress. 6 / 6
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"Fortilin Alleviated OTUD3 Knockdown Induced ER Stress."
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"Downregulation of OTUD3 reduced the binding ability of Fortilin to IRE1α, thereby activating the IRE1α pathway and inducing ER stress and neuronal apoptosis."
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"In the present study, our results demonstrated that OTUD3 knockdown-induced ER stress and cell apoptosis through the activation of the IRE1α pathway but not the PERK or ATF6α pathways."
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"Our data indicated that the ER stress caused by OTUD3 knockdown might be related the Fortilin expression."
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"These results suggested that OTUD3 knockdown would induce ER stress in dopaminergic neurons both in vivo and in vitro."
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"To explore which ER stress pathway was activated by OTUD3 knockdown, we detected the protein expression of the three pathways separately."
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