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Berberine inhibits NLRP3. 11 / 11
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"Berberine, an active component of coptis chinensis, can inhibit the activation of ROS-dependent NLRP3 inflammatory bodies and reduce the synthesis of pro-IL-1β by inhibiting NF-κB, so it can be used in the prevention and treatment of atherosclerosis (Ju et al., 2018)."
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"Berberine suppresses influenza virus triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS."
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"Berberine attenuates uric acid-induced cell injury by inhibiting NLRP3 signaling pathway in HK-2 cells."
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"Berberine can also inhibit the activation of the NLRP3 inflammasome by upregulating the level of macrophage autophagy."
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"There was evidence that berberine inhibited NLRP3 inflammasome pathway in MDA-MB-231 cell (Yao et al., 2019)."
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"Moreover, berberine prevented influenza virus-induced NLRP3 activation by promoting mitophagy and reducing mitochondrial oxidative stress (Liu et al., 2020a)."
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"Berberine inhibits NLRP3 Inflammasome pathway in human triple negative breast cancer MDA-MB-231 cell."
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"Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1beta."
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"Berberine inhibited hepatic necroinflammation, IL-1beta, and NLRP3 inflammasome in non alcoholic steatohepatitis (NASH) induced by methionine and choline - deficient diet in mouse, which based on interference with activation of P2x7, a purinergic receptor involved in inflammasome activation."
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"The alkaloids, berberine and ligustrazine, were found to inhibit the NLRP3 inflammasome."
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"Liu et al. observed that berberine inhibited NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in the influenza virus as well as a decline in ROS generation (Liu et al., 2020)."
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