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Berberine inhibits NLRP3. 26 / 26
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"Berberine, an isoquinoline alkaloid extracted from the Chinese herb Coptis chinensis and various Berberis plants, (Song et al., 2020), inhibits NLRP3 inflammasomes to mitigate neuroinflammatory responses, enhances synaptic plasticity and neurogenesis, and improves neuronal degeneration, thereby exhibiting its antidepressant effect (Qin et al., 2023)."
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"Yao et al (33) found that berberine could inhibit the proliferation and migration of triple-negative breast cancer cells by inhibiting the NLRP3 pathway."
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"Our research revealed that berberine pretreatment reduced the activation of NLRP3 inflammasome and the associated protein expression in microglia, indicating the anti-inflammatory action of Berberine [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Berberine has been shown to inhibit the activation of the NLRP3 inflammasome through mitophagy ."
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"Liu et al. have reported that berberine inhibits the activation of the NLRP3 inflammasome induced by influenza virus in macrophages by inducing mitophagy and decreasing mitochondrial ROS (Liu et al., 2020b)."
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"Berberine, a traditional Chinese medicine utilized for gastrointestinal diseases, has been shown to inhibit the TLR4 signaling pathway and suppress the transmission of the priming signal of NLRP3, effectively reducing the severity of GVHD in the lungs, liver, and colon."
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"Previous studies have reported that berberine inhibited NLRP3 activation, which in turn reduced IL-1β and IL-18 generations ( Vivoli et al., 2016 )."
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"The alkaloids, berberine and ligustrazine, were found to inhibit the NLRP3 inflammasome."
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"Berberine attenuates uric acid-induced cell injury by inhibiting NLRP3 signaling pathway in HK-2 cells."
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"Berberine inhibited hepatic necroinflammation, IL-1beta, and NLRP3 inflammasome in non alcoholic steatohepatitis (NASH) induced by methionine and choline - deficient diet in mouse, which based on interference with activation of P2x7, a purinergic receptor involved in inflammasome activation."
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"Berberine inhibits NLRP3 Inflammasome pathway in human triple negative breast cancer MDA-MB-231 cell."
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"Berberine repressed NLRP3 inflammasome pathway in triple-negative breast cancer [41]."
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"For example, berberine inhibited the high-mobility group box1 (HMGB1) protein/toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) pathway [ 75, 76] and inactivated NLRP3 inflammasome through activating AMPK signaling pathway [77, 78]."
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"Berberine activates AMP kinase, inhibits the NLRP3 inflammasome, stimulates the insulin receptor, and induces the low-density lipoprotein receptor."
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"Moreover, berberine prevented influenza virus-induced NLRP3 activation by promoting mitophagy and reducing mitochondrial oxidative stress (Liu et al., 2020a)."
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"Berberine attenuates the formation of NLRP3 inflammasomes, inhibits NF-κB and PI3K/AKT signaling pathways, suppresses the release of inflammatory mediators, bolsters intracellular antioxidant capacity, thereby mitigating oxidative stress and inflammatory responses, fostering the restoration of the intestinal barrier and reinstating normal function of intestinal epithelial cells, and shielding cells from damage."
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"Berberine Attenuates NLRP3 Inflammasome Activation in Macrophages to Reduce the Secretion of Interleukin-1beta."
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"There was evidence that berberine inhibited NLRP3 inflammasome pathway in MDA-MB-231 cell (Yao et al., 2019)."
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"Berberine, an active component of coptis chinensis, can inhibit the activation of ROS-dependent NLRP3 inflammatory bodies and reduce the synthesis of pro-IL-1β by inhibiting NF-κB, so it can be used in the prevention and treatment of atherosclerosis (Ju et al., 2018)."
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"Liu et al. observed that berberine inhibited NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in the influenza virus as well as a decline in ROS generation (Liu et al., 2020)."
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"In in vitro and in vivo studies of NAFLD, berberine has been shown to reduce pyroptosis by regulating the ROS/NLRP3 pathway (Mai et al., 2020)."
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"As revealed by western blotting and immunofluorescence labeling, the current data suggest that the NLRP3 signaling pathway was activated in CORT-induced depression mice, while berberine downregulated the NLRP3 signaling pathway in the hippocampus and PFC."
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"Berberine can also inhibit the activation of the NLRP3 inflammasome by upregulating the level of macrophage autophagy."
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"Besides, VR may inhibit the FD-4 absorption by decrease the permeability in jejunum.Using animal obesity models, studies have revealed that RC alkaloids and berberine could decrease mice body or organ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhou et al. [29] found that berberine can inhibit the activation of NLRP3 inflammasome by up-regulating the autophagy level of macrophages to inhibit the inflammatory response."
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"Berberine suppresses influenza virus triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS."
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