IndraLab

Statements

USP2 inhibits TP53. 11 / 11
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"USP2 additionally prevents p53 signaling."
33530560
eidos
"USP2 additionally prevents p53 signaling ."
33530560
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"Since Mdm2 is responsible for p53 degradation, USP2 could negatively regulate the p53 pathway activity through up-regulation of Mdm2."
18755030
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"Overexpression of USP2 was also shown to reduce p53 stability [XREF_BIBR], and another de-ubiquitylase USP8 (also called UBPY) promotes epithelial growth factor receptor degradation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25366495
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"Our data demonstrate that USP2 inhibition activates p53 function by destabilizing VPRBP and that it does so without compromising p53-Mdm2 feedback loop."
37024504
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"Overexpression of USP2 was shown to reduce p53 stability, conversely suppression led to destabilisation of MDM2 and increased p53 level and activation (9)."
20073038
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"To test whether USP2 could block p53 via Mdm2, we silenced USP2 and measured Mdm2 level by western blot in MyLa2000 cells after nutlin3a treatment."
27351221
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"Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy."
37024504
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"Inhibition of USP2 activates p53 but Mdm2-mediated regulation of p53 is largely unaffected."
37024504
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"Here we show that VPRBP levels are tightly controlled by USP2, a deubiquitinase that binds and stabilizes VPRBP, and that loss of USP2 function can activate p53 responses, including its tumor suppressive effects."
37024504
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"We postulate that upregulation of USP2 antagonizes p53 effect via deubiquitination of Mdm2."
27351221