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Statements

SRC activates KCND3. 7 / 10
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"At present, it is unclear how c-Src activates Kv4.3."
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"In support of this view, application of recombinant c-Src to the whole-cell patches further increased the current density possibly by stimulating the uncoupled Kv4.3 channels (see Fig. 5 C )."
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"Taken together, these data demonstrate that the transient outward Kv4.3 current can be constitutively upregulated by c-Src tyrosine kinase activity.There is evidence suggesting that signaling pathways[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To address whether c-Src modulation of Kv4.3 macroscopic currents involves remodeling of Kv4.3 channels at the plasma membrane, cells were treated with the Src kinase inhibitor PP2 (10 μM; 30 min), th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recombinant active c-Src and the tyrosine phosphatase inhibitor bpV(phen) caused an upregulation of Kv4.3 current amplitude in transfected HEK293 cells, whereas the Src kinase inhibitor PP2 decreased [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"At present, it is unclear how c-Src activates Kv4.3."
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"Here, we demonstrate that Kv4.3 channel activity is increased by c-Src."
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