IndraLab

Statements

OTUD3 inhibits MAVS. 6 / 6
| 6
reach
"All these results indicate that OTUD3 represses MAVS aggregation and thus inhibits MAVS-mediated antiviral signaling.The findings reported above raised the question of how hosts respond rapidly to vir[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32679077
reach
"Coinciding with these observations, the overexpression of OTUD3 markedly inhibited the self-association of RIG-I and MDA5, as well as the association of MAVS with RIG-I or MDA5 ( Figures S4 E–S4H)."
35675783
reach
"In contrast, knockdown OTUD3 in HEK293T by CRISPR-Cas9 cells enhanced the self-association of RIG-I and MDA5, and the association of MAVS with RIG-I or RIG-I or MDA5 ( Figures S4 I–S4L)."
35675783
reach
"For example, OTUD3 removes K63-linked ubiquitin chains from MAVS and thereby inhibits MAVS aggregation and IFN-I signaling activation (65)."
34707613
reach
"Re-expression of OTUD3 in Otud3 −/− MEFs repressed this increased MAVS aggregation, but re-expression of OTUD3 CS expression did not ( Figure S3 D)."
32679077
reach
"Interferon induces downregulation of CYLD to promote RIG-I K63-linked ubiquitination for its activation (132) and reduces OTUD3 expression to allow MAVS to undergo K63-linked ubiquitination and activation (158)."
35795661