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USP1 activates SNAI1. 6 / 6
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"USP1 upregulated SNAIL expression through deubiquitination to increase CXCL1 expression ."
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"Together, these data indicate that phosphorylation of USP1 on S/TQ motifs by ATM and ATR is a critical step for USP1-mediated Snail stabilization."
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"In accordance with the above experiments, ATM and, even more, ATR inhibitors strongly reduced CDDP-induced USP1 S42 phosphorylation (Fig. 4D) and eventually reduced Snail half-line in CDDP-treated cells (fig."
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"USP1 was reported to mediate drug resistance to platinum in ovarian cancer cells by regulating the stability of Snail, which, in turn, promotes tumor dissemination [ 23 ]."
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"22 They found that USP1 mediated resistance to platinum by stabilizing Snail and then promoting tumour dissemination."
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"In ovarian cancer cells, targeted USP1 knockout reduces cisplatin resistance cells by regulating the stability of Snail [15]."
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