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USP19 increases the amount of TBK1. 1 / 1
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"Down-regulation of USP19 increased the phosphorylation levels of TBK1 and IRF3 and inhibited autophagy induced by IAV infection due to the ubiquitination of Beclin1[129], indicating that Cyanidin and C3G showed anti-influenza virus activity against IAV infection by regulating USP19-Beclin1-dependent autophagy."