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CYLD activates cell population proliferation. 29 / 31
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"The present study investigated whether abnormal ectopic CYLD expression is sufficient to promote the proliferation of HCC827 and Calu-3 cells."
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"CYLD downregulation reversed the inhibitory effects of the proliferation of melanoma cells A375 and WM35 after transfection with miR-767-in."
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"CYLD deficiency leads to spontaneous B-cell activation and proliferation."
32850399
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"Elimination of SRF by siRNA or inhibition of p38 MAPK reduced the expression level of CYLD and increased cell proliferation."
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"To conclude, we found that downregulation of CYLD induces tumor cell proliferation, consequently contributing to the aggressive growth of HCC."
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"In conclusion, we demonstrated that CYLD downregulation promoted NPC cell proliferation and apoptosis resistance."
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"Knockdown of CYLD significantly increased the proliferation activities of two melanoma cell lines (p < 0.05), along with BCL3 nuclear translocation followed by CCND1 overexpression."
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"CYLD has also been shown to deubiquitinate (and inactivate) the coactivator BCL-3 (117) , which switches the transcriptional properties of NF-jB from repressive to activating, and is known to strongly promote cell proliferation and oncogenesis (118, 119) ."
20073038
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"CYLD deficiency promotes cancer cell proliferation, cell survival and tumorigenesis."
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"Our knockout and overexpression results consistently show the CYLD expression inhibits NPC cell proliferation and delays cell transition from early S to G2 phase in the cell cycle in vitro."
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"Collectively, this confirms that CYLD mediates cell proliferation and plays an important role to suppress NPC tumorigenicity."
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"We performed colony formation assays and anchorage independent growth assay to further confirm that CYLD downregulation reversed the inhibitory effects of the proliferation of melanoma cells A375 and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD deficiency also promoted cancer cell proliferation, survival, glucose uptake and growth of prostate tumors."
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"CYLD has also been shown to deubiquitinate (and inactivate) the coactivator BCL‐3 (117), which switches the transcriptional properties of NF‐κB from repressive to activating, and is known to strongly promote cell proliferation and oncogenesis (118, 119)."
20073038
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"Thus, our data demonstrated that inactivation of CYLD could promote CHO cell proliferation, anti-apoptosis ability, and subsequent antibody production, suggesting that CYLD is a potential functional target for CHO cell engineering."
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"Silencing of CYLD expression reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation."
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"Interestingly, in melanoma cells, SNAIL has been shown to inhibit expression of CYLD, which in turn leads to increased melanoma proliferation and invasion [XREF_BIBR]."
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"In this study we demonstrate that lack of CYLD expression in CYLD-/- MEFs increases proliferation rate of these cells compared to CYLD +/+ in a serum concentration dependent manner without affecting cell survival."
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"Knockdown of CYLD promoted cell proliferation of lung cancer cells."
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"CYLD deficiency also promoted cancer cell proliferation, survival, glucose uptake, and, when injected into mice, growth of prostate tumors."
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"In p18 knockdown HK1-EBV and HONE1-EBV cells, overexpression of CYLD did n't inhibit cell proliferation."
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"Further functional experiments revealed that the suppression of CYLD reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Downregulation of CYLD induced tumor cell proliferation and consequently contributed to the aggressive growth of hepatocellular carcinoma [XREF_BIBR]."
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"Knockdown of CYLD by siRNA Promotes Cell Proliferation of A549 and H460 Cells."
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"Furthermore, pre-treatment of CYLD +/+ MEFs with SB203580, which is also an inhibitor of MK2, increased proliferation rate of these cells compared to control treated cells (XREF_FIG)."
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"Collectively , this confirms that CYLD mediates cell proliferation and plays an important role to suppress NPC tumorigenicity ."
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"Additional findings that miR-186 directly targets cylindromatosis (CYLD), thereby promoting cell proliferation of human melanoma cells."
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"Colony formation and anchorage independent growth assays demonstrated that knockout of CYLD expression significantly reversed the miR-1288-in-induced promotion of GBM cell proliferation (XREF_FIG)."
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