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CYLD activates cell population proliferation. 31 / 33
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"Silencing of CYLD expression reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Collectively , this confirms that CYLD mediates cell proliferation and plays an important role to suppress NPC tumorigenicity ."
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"Elimination of SRF by siRNA or inhibition of p38 MAPK reduced the expression level of CYLD and increased cell proliferation."
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"In this study we demonstrate that lack of CYLD expression in CYLD-/- MEFs increases proliferation rate of these cells compared to CYLD +/+ in a serum concentration dependent manner without affecting cell survival."
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"CYLD deficiency leads to spontaneous B-cell activation and proliferation."
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"The present study investigated whether abnormal ectopic CYLD expression is sufficient to promote the proliferation of HCC827 and Calu-3 cells."
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"Colony formation and anchorage independent growth assays demonstrated that knockout of CYLD expression significantly reversed the miR-1288-in-induced promotion of GBM cell proliferation (XREF_FIG)."
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"Furthermore, pre-treatment of CYLD +/+ MEFs with SB203580, which is also an inhibitor of MK2, increased proliferation rate of these cells compared to control treated cells (XREF_FIG)."
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"Further functional experiments revealed that the suppression of CYLD reversed the cell proliferation promotion by miR-1288-in in GBM."
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"Additional findings that miR-186 directly targets cylindromatosis (CYLD), thereby promoting cell proliferation of human melanoma cells."
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"CYLD has also been shown to deubiquitinate (and inactivate) the coactivator BCL‐3 (117), which switches the transcriptional properties of NF‐κB from repressive to activating, and is known to strongly promote cell proliferation and oncogenesis (118, 119)."
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"Advanced prostate cancer is associated with low CYLD abundance and the absence of CYLD stimulates prostate cancer cell proliferation and survival [ 27 ]."
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"To conclude, we found that downregulation of CYLD induces tumor cell proliferation, consequently contributing to the aggressive growth of HCC."
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"Our knockout and overexpression results consistently show the CYLD expression inhibits NPC cell proliferation and delays cell transition from early S to G2 phase in the cell cycle in vitro."
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"Collectively, this confirms that CYLD mediates cell proliferation and plays an important role to suppress NPC tumorigenicity."
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"In conclusion, we demonstrated that CYLD downregulation promoted NPC cell proliferation and apoptosis resistance."
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"CYLD ablation leads to NF-kappaBeta signaling activation and increased proliferation in SMZL cell lines."
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"Thus, our data demonstrated that inactivation of CYLD could promote CHO cell proliferation, anti-apoptosis ability, and subsequent antibody production, suggesting that CYLD is a potential functional target for CHO cell engineering."
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"Interestingly, in melanoma cells, SNAIL has been shown to inhibit expression of CYLD, which in turn leads to increased melanoma proliferation and invasion [XREF_BIBR]."
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"CYLD deficiency also promoted cancer cell proliferation, survival, glucose uptake and growth of prostate tumors."
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"Downregulation of CYLD induced tumor cell proliferation and consequently contributed to the aggressive growth of hepatocellular carcinoma [XREF_BIBR]."
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"CYLD deficiency promotes cancer cell proliferation, cell survival and tumorigenesis."
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"Knockdown of CYLD significantly increased the proliferation activities of two melanoma cell lines (p < 0.05), along with BCL3 nuclear translocation followed by CCND1 overexpression."
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"We performed colony formation assays and anchorage independent growth assay to further confirm that CYLD downregulation reversed the inhibitory effects of the proliferation of melanoma cells A375 and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CYLD downregulation reversed the inhibitory effects of the proliferation of melanoma cells A375 and WM35 after transfection with miR-767-in."
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"In p18 knockdown HK1-EBV and HONE1-EBV cells, overexpression of CYLD did n't inhibit cell proliferation."
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"Knockdown of CYLD by siRNA Promotes Cell Proliferation of A549 and H460 Cells."
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"For example, the deubiquitinating enzyme CYLD can promote cell survival, proliferation, and differentiation, and plays key roles in regulating inflammatory and natural immune responses."
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"Knockdown of CYLD promoted cell proliferation of lung cancer cells."
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"Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation."
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"Furthermore, other recent studies have shown that CYLD expression is frequently reduced in human HCC and that downregulation of CYLD induced tumor cell proliferation, which consequently contributed to[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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