IndraLab

Statements

P5091 inhibits apoptotic process. 12 / 12
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"The small molecule inhibitor, P5091, is an inhibitor of USP7 and induces apoptosis in Multiple Myeloma cells [12]."
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"Inhibition of Usp7 with the selective inhibitor P5091 induces apoptosis in MM cells resistant to conventional therapy and acts synergistically with the HDAC inhibitor SAHA, lenalidomide and dexamethasone."
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"The USP7 inhibitor P5091 induces apoptosis in GBM cells."
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"We first determined that the USP7 inhibitor P5091 reduced cells growth in two SCLC H526 and H209 cell lines, by inducing apoptosis."
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"P5091 has also been reported to inhibit colorectal tumor growth in an HCT116 xenograft mouse model by suppressing proliferation and inducing apoptosis in CRC cells [221]."
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"One such inhibitor, P5091, is highly selective against USP7 and has been shown to induce apoptotic cell death in therapy resistant multiple myeloma cells ."
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"The USP7 inhibitor P5091 has been reported to induce apoptosis of multiple myeloma (MM) cells, and synergistic anti-MM effects can be exerted by multiple drugs."
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"The DUB inhibitors P5091 and WP1130 could significantly induce apoptosis in both naïve and PI‐tolerant cells to varying degrees (Figure S2A)."
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"Furthermore, a selective USP7 inhibitor, P5091, was found to induce apoptosis in multiple myeloma cells that are resistant to conventional anti-cancer therapies [XREF_BIBR]."
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"Another selective USP7 inhibitor, P5091 (Fig. 2L), was able to induce apoptosis in multiple myeloma cells resistant to conventional and Bortezomib therapies [120].2.5.3 USP14 inhibitor."
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"Through high-throughput screening, scientists identified another novel USP7 inhibitor, the thiophenyl compound P5091, which induces apoptosis in BTZ-resistant MM cells."
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"Interestingly, P5091 treatment decreased the growth of L-NEC cell lines by inducing apoptosis."
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