IndraLab

Statements

SHPK inhibits KCNA3. 5 / 5
| 1 2 2
eidos
"Although it inhibits several KV subtypes , ShK most potently blocks KV1.3 with an IC50 of ~ 10 pM ."
31159357
sparser
"As described previously [ xref , xref ], ShK inhibited Kv1.3 and Kv1.1 channels with similar potencies (IC 50 of 9 ± 2 pM for Kv1.3 and 23 ± 3 pM for Kv1.1)."
23063513
sparser
"Engineered variants of ShK, OsK1 and OdK2 that potently and selectively inhibit Kv1.3 have also been identified [ xref , xref ]."
28107393
reach
"Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3."
37040361
reach
"STH secrete immunoregulatory molecules that act directly on T cells, typified by the hookworm homologues of sea anemone ShK toxins that block Kv1.3 voltage-gated potassium channels and are crucial for the activation of effector memory T cells (Smallwood et al., 2021)."
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