IndraLab

Statements

OTULIN inhibits RIPK1. 2 / 4
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"Formation of the secondary, receptor-free cytoplasmic complex II is largely dependent on the activity of DUBs, specifically cylindromatosis (CYLD), A20 (also known as TNFAIP3) and ubiquitin thioesterase OTULIN, which destabilize complex I, abrogate NF-kappaB activation and release RIPK1 from complex I, which then forms the cytosolic complex II XREF_BIBR, XREF_BIBR."
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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