IndraLab

Statements

OTULIN inhibits RIPK1. 7 / 9
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"OTULIN also prevents liver inflammation and HCC by inhibiting FADD and RIPK1 kinase-mediated hepatocyte apoptosis [122]."
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"OTULIN promotes rather than counteracts LUBAC activity by preventing its auto-ubiquitination with linear polyubiquitin [78], and OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice [79]."
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"Formation of the secondary, receptor-free cytoplasmic complex II is largely dependent on the activity of DUBs, specifically cylindromatosis (CYLD), A20 (also known as TNFAIP3) and ubiquitin thioesterase OTULIN, which destabilize complex I, abrogate NF-kappaB activation and release RIPK1 from complex I, which then forms the cytosolic complex II XREF_BIBR, XREF_BIBR."
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"By contrast, OTULIN acts specifically on linear ubiquitin linkages and prevents association of NEMO with ubiquitinylated RIPK1, which in turn thwarts the colocalization of TAK1 and IKK complexes, thus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice."
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"OTULIN prevents liver inflammation and hepatocellular carcinoma by inhibiting FADD- and RIPK1 kinase-mediated apoptosis in hepatocytes [55]."
37813853
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"When the deubiquitinating enzymes A20, CYLD, and OTULIN degrade the ubiquitin chain of RIPK1, complex I dissociate, and the released RIPK1 forms the cytoplasmic death-induced signaling complex (DISC), Complex IIa, or complex IIb, inducing programmed cell death (7)."
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