IndraLab

Statements

USP7 activates CTNNB1. 6 / 6
| 6
reach
"23, 24, 25 NSCLC studies have shown that high expression levels of USP5 and USP7 in lung cancer tissue promote lung cancer cell proliferation by stabilizing beta-catenin."
33619866
reach
"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
30542736
reach
"USP7 was also shown to promote cancer by stabilizing beta-catenin and inducing signaling regulating cell fate determination and migration via the Wnt pathway [XREF_BIBR]."
| PMC
reach
"Moreover, USP7 can up-regulate β-catenin, suggesting the potential of USP7 as a therapeutic target in colorectal cancer with a hyperactivated Wnt signaling, to suppress growth and overcome chemoresistance to Wnt inhibitors (An et al., 2017)."
33967786
reach
"Genetic ablation or pharmacological inhibition of USP7 robustly increases Wnt/beta-catenin signaling in multiple cellular systems."
31519875
reach
"Genetic ablation or pharmacological inhibition of USP7 robustly increases Wnt and beta-catenin signaling in multiple cellular systems."
31519875