IndraLab

Statements

USP7 activates CTNNB1. 11 / 11
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"For example, the β-catenin degradation through ubiquitin-dependent proteolysis is prevented by several deubiquitinating enzymes including USP6N, USP4 and USP7 [ 167–169 ]."
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"Overall, USP7 overexpression could promote OS cell metastasis by activating the Wnt and beta-catenin signalling pathway by inducing EMT, suggesting that USP7 is a potential therapeutic target for OS."
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"Genetic ablation or pharmacological inhibition of USP7 robustly increases Wnt/beta-catenin signaling in multiple cellular systems."
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"Moreover, USP7 can up-regulate β-catenin, suggesting the potential of USP7 as a therapeutic target in colorectal cancer with a hyperactivated Wnt signaling, to suppress growth and overcome chemoresistance to Wnt inhibitors (An et al., 2017)."
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"USP7 was also shown to promote cancer by stabilizing beta-catenin and inducing signaling regulating cell fate determination and migration via the Wnt pathway [XREF_BIBR]."
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"23, 24, 25 NSCLC studies have shown that high expression levels of USP5 and USP7 in lung cancer tissue promote lung cancer cell proliferation by stabilizing beta-catenin."
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"Ubiquitination of USP7 enzyme activated β-catenin pathway, thus promoting progression of CRC (23)."
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"USP7 enhances Wnt signaling activity by stabilizing the β-catenin protein, which contributes to tumor growth."
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"Furthermore, we show that pharmacological inhibition of USP7 by its inhibitor P5091 decreases the abundance of β-catenin and attenuates the activity of Wnt signaling pathway in both HEK293 cells trans[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Contrarily, it is known in the literature that USP7 deubiquitinase activity rescues β-catenin protein from proteasomal degradation via its interaction with E3 ligase RNF220."
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"Thus, USP7 also upregulates the β-catenin stability (Ma et al., 2014)."
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