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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FOXO1 activates SCN5A. 2 / 2

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"Elevated levels of reactive oxygen species (ROS) in IHD [XREF_BIBR - XREF_BIBR] induced the nuclear localization of FoxO1 in both HL-1 [XREF_BIBR] and rat neonatal cardiomyocytes [XREF_BIBR] potentially through acetylation [XREF_BIBR] and phosphorylation at serine 212 by mammalian sterile 20 like kinase 1 [XREF_BIBR] and suppresses Na V 1.5 expression through FoxO1 mediation of the SCN5a promoter activity [XREF_BIBR]."

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"In this study, we demonstrated that Foxo1 directly targeted the SCN5a promoter and inhibited its transcriptional activity."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...