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USP47 activates EZH2 inhibitors. 1 / 1

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"USP47 inhibition blocked the function of mutated EZH2 through ubiquitination and EZH2 degradation, increasing the sensitivity of diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) cells to EZH2 inhibitors, such as the recently FDA-approved EPZ-6438, in vitro and in vivo ."

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USP47 activates EZH2 inhibitors. 1 / 1

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