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USP46 increases the amount of STK4. 5 / 5
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"As a deubiquitinating enzyme, USP46 is responsible for the process of protein deubiquitination, and we hypothesized that USP46 mediated the upregulation of MST1 by modulating the ubiquitination level [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Scientifically, USP46 stimulates MST1 expression, which in turn antagonizes YAP1 to inhibit the development of HCC by promoting the breakdown of YAP1."
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"Overexpression of USP46 increased protein expression of MST1, phosphorylated MST1 and phosphorylated LATS1 ( Fig. 5 B)."
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"In addition, overexpression of USP46 increased ectopic expression of MST1 in a dose-dependent manner ( Fig. 6 E)."
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"Our results indicate that the regulatory axis by which USP46 promotes the degradation of YAP1 by upregulating MST1 expression also exists in HCC tissues.As a deubiquitinating enzyme, USP46 is involved[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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