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USP9X deubiquitinates YAP1. 14 / 15
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"YAP1 is deubiquitinated and stabilized by USP9X, thereby promoting breast cancer cell survival and resulting in chemotherapy resistance (47)."
37920433
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"A previous study demonstrated that deubiquitinase USP9X could interact with and deubiquitinate YAP, and then enhanced its protein stability.25 Interestingly, the results of RNA pull-down followed by mass spectrometry analysis demonstrated that USP9X potentially associated with LINC01433."
31632054
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"Mechanistically, it was found that hsa_circ_0024093 could regulate the expression of USP9X, which further induced YAP1 deubiquitination to stabilize YAP1 protein."
34631281
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"Conversely, the deubiquitinating enzyme (DUB) ubiquitin specific peptidase 9 X-linked (USP9X) deubiquitinates and stabilizes YAP1, thereby promoting breast cancer cell survival and chemotherapy resist[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38537774
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"It has been previously reported that the deubiquitination enzyme USP9X deubiquitinates and stabilizes YAP in breast cancer cells, thus promoting cancer cell survival [13]."
37349820
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"In addition, it has been shown that USP9X induces YAP1 deubiquitination to enhance cell proliferation and metastasis in breast carcinoma.18 Thus, we further speculated whether hsa_circ_0024093 could affect USP9X to promote YAP1 deubiquitination and stabilize YAP1 protein."
34631281
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"USP9X induces YAP1 deubiquitination to stabilize YAP1."
34631281
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"Mechanistically, USP9X deubiquitinates and stabilizes YAP1."
29449692
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"Furthermore, the ubiquitination of YAP1 was reduced by USP9X upregulation in VSMCs and increased by USP9X knockdown in PDGF-BB-treated VSMCs (Figures S4E and S4F)."
34631281
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"Here we demonstrate that the deubiquitination enzyme USP9X deubiquitinates and stabilizes YAP1, thereby promoting cancer cell survival."
29449692
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"For instance, USP9X promotes breast cancer cell survival and attenuates cell sensitivity to chemotherapy by deubiquitinating and stabilizing YAP [128]."
36497313
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"For instance, USP9X, ubiquitin-specific peptidase 47 (USP47), and OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) directly deubiquitinate YAP [33–35]."
37743467
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"Several studies have elucidated that a deubiquitinase, DUB3, regulates YAP/TAZ activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT family proteins.16 Recently, it was reported that the deubiquitination enzyme USP9X deubiquitinates and stabilizes YAP1, thereby promoting cancer cell survival."
31393050
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"Since YAP1 plays a key role in human cancer development, it is possible that USP9X promotes deubiquitination and stabilization of YAP1 in human cancers."
29449692