IndraLab

Statements

(+)-artemisinin inhibits NFKB1. 3 / 3
| 3
reach
"Therefore, given the observed effects of artemisinin disrupting the binding of NF-kappaB subunits p65 and p50 to the CDK4 promoter, we investigated whether artemisinin disrupts NF-kappaB localization into the cell nuclei."
24296733
reach
"To determine if one or more of these sites plays a role in conferring artemisinin responsiveness to the CDK4 promoter, chromatin immunoprecipitation was used to directly determine whether artemisinin disrupts the endogenous interactions of Sp1, AP-1, p50, and p65 with the CDK4 promoter."
24296733
reach
"Our results provide direct evidence that artemisinin disrupts interactions of the p50 and p65 subunits of NF-kB with a critical cell cycle target gene promoter to mediate an anti-proliferative response in human endometrial cancer cells."
24296733