IndraLab

Statements

CLSPN activates USP7. 4 / 4
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"To clarify whether Claspin is a direct target of USP7, we tested whether the two proteins copurify in immunoprecipitation (IP) experiments."
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"USP7 targets Claspin, another damage response mediator protein, to prevent its degradation."
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"Only a slight increase in Chk1 levels was evident under these conditions, which further supports the notion that Claspin rather than Chk1 is a target of USP7."
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"By protecting Claspin from degradation, USP7 may directly impact the initiation as well as termination of Chk1 mediated signaling responses, and hence it will be important to address if and how the Claspin directed activity of USP7 is itself regulated during checkpoint responses."
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