IndraLab

Statements

FTO increases the amount of OTUB1. 7 / 7
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"FTO acts as an m6A demethylase to remove m6A modification from OTUB1 transcripts, promoting OTUB1 expression and effectively inhibiting ferroptosis [87]."
38785921
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"In nasopharyngeal carcinoma radiotherapy, the demethyltransferase FTO promotes the expression of deubiquitylase (OTUB1) expression to counter ferroptosis and bolster the nasopharyngeal carcinoma radioresistance [51]."
38473842
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"FTO acts as a m6A demethylase, eliminating the m6A modification of the OTUB1 (Ovarian Tumor Family Deubiquitinase) transcript and promoting the expression of OTUB1, which protects against radiation-induced ferroptosis (Koppula et al. 2021)."
39972266
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"Mechanically, FTO, as a M6A demethylase, clears the M6A modification of the OTUB1 transcripts and consequently enhances the expression of OTUB1, thereby promoting OTUB1-mediated antiferroptosis and NPC radioresistance [51]."
38473842
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"FTO enhanced OTUB1 expression via m6A demethylation, stabilizing SLC7A11, and inhibiting ferroptosis to alleviate cerebral I/R injury."
40233842
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"Our studies revealed that FTO increases OTUB1 expression by removing m6A modifications from OTUB1 transcripts, thus impeding ferroptosis induced by radiation in NPC cells [13]."
39128424
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"FTO removes m A modification of OTUB1 transcripts and promotes the expression of OTUB1."
38550378