IndraLab

Statements


Cyclin activates CYLD. 4 / 4
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"Interestingly, TPA also triggered the recruitment of p50 or p52, but not p65, to the cyclin D1 promoter in Cyld -/- keratinocytes."

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"TNF-alpha treatment failed to activate the cyclin D1 promoter in Cyld +/+ as well as Cyld -/- keratinocytes, consistent with the inability of TNF-alpha to stimulate keratinocyte proliferation."

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"Importantly, the increased cyclin D1 promoter activity in Cyld -/- keratinocytes was normalized after re-expression of Cyld and completely abolished in the absence of a functional NF-kappaB binding si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The increased cyclin D1 activation in Cyld -/- keratinocytes was normalized upon reintroduction of the Cyld protein."