IndraLab

Statements

CYLD inhibits RIPK2. 7 / 7
| 1 5 1
reach
"CYLD has been reported to inhibit RIPK2 induced signaling when overexpressed, but the function of endogenous CYLD in NOD2 signaling remains unexplored and its role as a DUB is unknown."
26997266
eidos
"Thus , inhibition of RIPK2 by CYLD leads to impaired pathogen control due to a reduction in antimicrobial responses including pro-inflammatory cytokine production , ROS and nitric oxide ( NO ) production ."
| PMC
reach
"Thus, the underlying infection determines the impact of RIPK2 and CYLD on the outcome of the disease and our identification of a direct inhibition of RIPK2 by CYLD provides a mechanistical explanation of the antagonistic effects of these two signaling molecules."
26834734
reach
"Thus, inhibition of RIPK2 by CYLD leads to impaired pathogen control due to a reduction in antimicrobial responses including pro inflammatory cytokine production, ROS and nitric oxide (NO) production."
| PMC
reach
"CYLD Impairs RIPK2 Mediated Activation and Antibacterial Function of BMDM."
26834734
reach
"Thus, inhibition of RIPK2 by CYLD leads to impaired pathogen control due to a reduction in antimicrobial responses including pro inflammatory cytokine production, ROS and nitric oxide (NO) production.Another recent study used kinase inhibitors to demonstrate functional specificity of the kinase domain of RIPK2 in controlling bacterial pathogens."
| PMC
sparser
"Thus, the underlying infection determines the impact of RIPK2 and CYLD on the outcome of the disease and our identification of a direct inhibition of RIPK2 by CYLD provides a mechanistical explanation of the antagonistic effects of these two signaling molecules."
26834734