IndraLab

Statements

CYLD inhibits RIPK2. 7 / 7
| 1 4 2
reach
"Thus, inhibition of RIPK2 by CYLD leads to impaired pathogen control due to a reduction in antimicrobial responses including pro inflammatory cytokine production, ROS and nitric oxide (NO) production."
| PMC
reach
"CYLD has been reported to inhibit RIPK2 induced signaling when overexpressed, but the function of endogenous CYLD in NOD2 signaling remains unexplored and its role as a DUB is unknown."
26997266
sparser
"Previously, we have shown that the inhibition of RIPK2 by CYLD impairs the activation of MAP kinases and ERK1/2-induced autophagy in Listeria monocytogenes -infected macrophages ( xref )."
39958342
eidos
"Thus , inhibition of RIPK2 by CYLD leads to impaired pathogen control due to a reduction in antimicrobial responses including pro-inflammatory cytokine production , ROS and nitric oxide ( NO ) production ."
| PMC
sparser
"Thus, the underlying infection determines the impact of RIPK2 and CYLD on the outcome of the disease and our identification of a direct inhibition of RIPK2 by CYLD provides a mechanistical explanation of the antagonistic effects of these two signaling molecules."
26834734
reach
"CYLD Impairs RIPK2 Mediated Activation and Antibacterial Function of BMDM."
26834734
reach
"Thus, the underlying infection determines the impact of RIPK2 and CYLD on the outcome of the disease and our identification of a direct inhibition of RIPK2 by CYLD provides a mechanistical explanation of the antagonistic effects of these two signaling molecules."
26834734