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Modified BAP1 decreases the amount of H3K27me3. 2 / 2

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"Recurrent BAP1 mutations have also been observed in intrahepatic cholangiocarcinoma 25, and a recent study showed that loss of Bap1 in mice increases expression of H3K27me3 and Ezh2 while suppressing expression of PRC2 targets 26."

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"Coexpression of ASXL1-MT and BAP1 also reduced bulk H3K27me3 levels, which is probably a direct consequence of loss of H2AK119Ub 24 in 32Dcl3 cells."

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IndraLab

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Modified BAP1 decreases the amount of H3K27me3. 2 / 2

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