IndraLab

Statements

COPS5 increases the amount of JUN. 3 / 4
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"Jab1 promotes the activation of c-Jun N-terminal kinase (JNK) and increases the level of endogenous phospho-c-Jun; MIF inhibits both of these processes (Kleemann et al., 2000)."
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"Jab1 also stabilizes certain proteins, such as hypoxia inducible factor 1alpha and c-Jun, and potentiates c-Jun and MYC transcription, which is responsible for the transcriptional activation of genes involved in cell proliferation, angiogenesis, and invasion."
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"Jab1 can enhance the c-Jun phosphorylation level through a CSN-associated kinase and stabilize the binding of c-Jun to AP-1 sites [10] ."
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