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BAP1 increases the amount of PTGES. 8 / 8
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"Accordingly, our data show that BaP1 induced a marked increase in protein expression of both COX-2 and mPGES-1, the increase in COX-2 expression occurring before that of mPGES-1."
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"We found that the EP4 receptor positively regulates BaP1-triggered PGE release and expression of COX-2 and mPGES-1, which are critically involved in the biosynthesis of PGE induced by this metalloprotease."
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"As shown in Fig. 5, pretreatment of cells with SN50 inhibited BaP1-induced COX-2 protein expression (Fig. 5C,D) and BaP1-induced mPGES-1 protein expression (Fig. 5G,H)."
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"Furthermore, our findings that BaP1 induced gene expression of COX-2 and mPGES-1 demonstrate that BaP1 can trigger transcriptional mechanisms in FLSs that result in increased protein expression."
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"Intriguingly, BAP1 was unfolded to increase the COX-2 and mPGES-1 expression by activating the NF-κB pathway (Viana et al. 2020)."
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"Gene and protein expression of both COX-2 and mPGES-1 are induced by BaP1 via activation of distinct subunits of the NF-κB transcription factor."
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"Partially consistent with our results, BAP1 was unfolded to increase the COX-2 and mPGES-1 expression by activating the NF-κB signaling pathway and inducing the release of IL-1β (Viana et al. 2020), but this study failed to explore the regulatory role of BAP1 mutations on the NF-κB signaling pathway."
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"Expression of COX-2 and mPGES-1 are induced by BaP1 via activation of NF-kappaB pathway."
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