IndraLab

Statements

USP8 activates CD47. 2 / 2
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reach
"In addition, USP8 regulates the ubiquitination level of ASCL1 and mediates CD47 transcriptional regulation of the AKT pathway to increase the glycolysis level of hBMSCs and cell osteogenic differentiation."
37783914
reach
"In the present study, our study confirmed that after transfection with si-CD47, hBMSCs showed reduced levels of glucose consumption and decreased levels of ATP production, lactate production, ALP activity, and mineralized nodules.In summary, this study indicates that USP8 ubiquitination regulates ASCL1 expression and mediates CD47 transcriptional activation of the AKT signaling pathway and that glycolysis promotes osteogenic differentiation of hBMSCs."
37783914