IndraLab

Statements

KCNMA1 binds PTK2. 11 / 12
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sparser
"Mapping of the FAK region interacting with hSlo was approached by testing the ability of hSlo to recruit mutated ot truncated FAK proteins."
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"Slo1 interacts with FAK to influence myogenic differentiation, and Slo1 deletion diminishes NFAT activity."
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sparser
"Slo1 interacts with FAK to influence myogenic differentiation."
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reach
"Unfortunately, we did not find the interaction between Slo1 and FAK from mass spectrometry results (Table S3)."
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reach
"Then we confirmed that Slo1 binds to FAK in primary mouse myoblasts by co‐immunoprecipitation (Figure 6F)."
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"IGF‐1 promotes the differentiation of skeletal myoblasts by activating the PI3K/Akt signalling pathway. xref Our previous study found that Slo1 knockout impaired the activation of FAK, xref and other research showed that Slo1 interacted with FAK in human myoblast. xref We, therefore, hypothesized that Slo1 might be able to interact with FAK to influence the FAK‐mediated PI3K‐Akt pathway."
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reach
"We show that FAK and hSlo interaction likely takes place through the Pro-1-rich domain situated in the C-terminal region of the kinase."
14584897
sparser
"Unfortunately, we did not find the interaction between Slo1 and FAK from mass spectrometry results (Table  xref )."
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sparser
"Then we confirmed that Slo1 binds to FAK in primary mouse myoblasts by co‐immunoprecipitation (Figure  xref )."
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trips
"We show that the mechanosensitive BK channels open and recruit the focal adhesion kinase FAK in osteoblasts on hypotonic shock."
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sparser
"Collectively, these results indicate that Slo1 interacts with FAK to influence PI3K‐AKT signalling during myoblast differentiation."
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