IndraLab

Statements

OTUD5 activates GPX4. 5 / 5
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"Collectively, our data illustrate that 4‐HNE triggers ubiquitin–proteasomal degradation of GPX4 in cardiomyocytes.2.5 OTUD5 Mediates 4-HNE-Induced GPX4 Degradation and Ferroptosis."
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"p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer."
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"We then asked if OTUD5 could prevent GPX4 degradation."
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"We further investigated whether OTUD5 protected renal tubular cells from H/R-induced ferroptosis by stabilizing GPX4."
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"Conversely, in gastric cancer cells harbouring p53 mutations, OTUD5 transcription is upregulated due to the inactivation of p53, allowing OTUD5 to stabilise GPX4 protein, inhibit ferroptosis and thereby promoting gastric cancer progression (Figure 6J, right panel)."
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