IndraLab

Statements

USP14 activates PRNP. 4 / 4
| 4
reach
"Collectively, a better understanding about the regulation of PrP Sc clearance caused by USP14 might contribute greatly to the development of therapeutic strategies for prion diseases."
26061634
reach
"Results demonstrated that an inhibitor of USP14 reduced PrP C in mouse neuroblastoma cells, as well as PrP Sc, indicating that USP14 negatively regulates degradation of prion protein."
26061634
reach
"Overexpression of the dominant negative mutant form of USP14 reduced PrP Sc, whereas wildtype USP14 increased PrP Sc in prion infected cells."
26061634
reach
"These results suggest that USP14 prevents degradation of both normal and abnormal PrP."
26061634