IndraLab

Statements

USP14 activates PRNP. 4 / 4
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"Collectively, a better understanding about the regulation of PrP Sc clearance caused by USP14 might contribute greatly to the development of therapeutic strategies for prion diseases."
26061634
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"Results demonstrated that an inhibitor of USP14 reduced PrP C in mouse neuroblastoma cells, as well as PrP Sc, indicating that USP14 negatively regulates degradation of prion protein."
26061634
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"Overexpression of the dominant negative mutant form of USP14 reduced PrP Sc, whereas wildtype USP14 increased PrP Sc in prion infected cells."
26061634
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"These results suggest that USP14 prevents degradation of both normal and abnormal PrP."
26061634