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USP8 decreases the amount of TIMP1. 2 / 2
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"In addition, the overexpression of USP8 reversed the decreased expression of MMP9, MMP2, and N-cadherin and high protein expression of TIMP-1, TIMP-2, and E-cadherin that was induced by SCNN1A silenci[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"This study showed that USP8 overexpression improved the expression of MMP2, MMP9, E-cadherin, and N-cadherin in the trophoblast cells and suppressed TIMP-1 and TIMP-2 expression; whereas knocking down[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"