IndraLab

Statements

OTULIN inhibits RNF31. 3 / 4
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"This interaction is negatively regulated by phosphorylation of OTULIN on Y56, thereby disrupting binding to HOIP and abrogating OTULIN-dependent suppression of LUBAC [ 29 , 30 ]."
34074601
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"Strikingly, while mice lacking OTULIN in B or Tcells do not display overt inflammatory phenotypes, further analysis indicates that these OTULIN deficient cells have downregulated LUBAC components HOIP and SHARPIN, but not HOIL-1."
27523608
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"Otulin deficiency in B or T cells led to downregulation of the LUBAC components HOIP and SHARPIN."
34157307