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USP5 activates Carcinogenesis. 8 / 8
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"Meanwhile, activation of ERK phosphorylates METTL3 and stabilizes its expression by increasing USP5-mediated deubiquitylation, resulting in ERK-activated cancer cell tumorigenesis [209]."
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"USP5 promotes tumorigenesis by activating Hedgehog/Gli1 signaling pathway in osteosarcoma."
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"Accumulating data suggest that overexpression of USP5 contributes to tumorigenesis in various cancer types through deubiquitinating and stabilizing oncoproteins, such as p53 in melanoma, c-Maf in multiple myeloma, Slug in hepatocellular carcinoma, or histone deacetylase 2 (HDAC2) in ovarian cancer [12]."
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"USP5 promotes tumorigenesis in HCC through the inactivation of p14 -p53 signaling."
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"It has been reported that USP5 promotes tumor proliferation and tumorigenesis through the deubiquitination of histone deacetylase 2 ( HDAC2 ) ( Du et al ., 2019 ) and beta-catenin ( Ma et al ., 2018 ) ."
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"USP5 expression promotes tumorigenesis in many cancers , like in non-small cell lung cancer overexpression of USP5 stabilizes the beta-catenin protein [ 13 ] ."
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"These current discoveries indicate that USP5 could be a potential therapeutic target for the treatment of various diseases, including cancer.Overexpression of histone deacetylases (HDACs) can lead to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP5 knockdown suppressed cell proliferation, migration, and drug resistance and induced apoptosis, while USP5 overexpression promoted colony formation, migration, drug resistance, and tumorigenesis (21)."
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