IndraLab

Statements



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"USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1."

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"These results indicated that USP19 enhanced cell proliferation and exhibited anti-apoptotic properties."

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"We previously reported that the USP19 deubiquitinating enzyme positively regulates proliferation in fibroblasts by stabilizing KPC1, a ubiquitin ligase for p27 Kip1."

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"In addition, CCK8 assay also proved that USP19 depletion inhibited the proliferation rate of Hep3B and Huh7 cells ( Fig. 5 E)."

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"The results showed that knockdown of USP19 suppressed cell proliferation in SGC7901 cells while overexpressing USP19 accelerated cell growth in GES1 cells, as determined by MTT assay (P < 0.01, XREF_FIG and XREF_FIG)."

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"Figure 5C, D shows that the cell proliferation and viability enhanced by TIPE3 overexpression was inhibited by silencing USP19."

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"Correspondingly, USP19 knockdown decreased proliferation, migration of HCC cells, which could be reversed by overexpression of YAP."

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"Flow cytometry was used to investigate the role of cell‐cycle disruption in the increased proliferation caused by USP19 overexpression."

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"The results showed that USP19 knockdown suppressed the proliferation, anchorage-independent growth and xenograft tumor formation of DLBCL cells and arrested the cell cycle at the G1 stage."

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"In addition, depletion of USP19 reduces cell proliferation and causes cell arrest at the G G1 phase and p27 stabilization [112]."

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"Reports indicate that the disruption of USP19 inhibits a series of PCa cell proliferation by arresting cells in the G1 to S phase transition through stabilization of the cyclin-dependent kinase inhibitor p27 ."