IndraLab

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USP1 increases the amount of TAFAZZIN. 7 / 7
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"Conversely, loss of function of USP1 reduces TAZ protein levels through increased poly-ubiquitination, causing a decrease in cell proliferation and migration of breast cancer cells."
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"Considering the deubiquitination properties of the USP1, we speculated that USP1 modulate TAZ expression through the proteasome pathway."
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"To further determine the association between USP1 and TAZ, we transfected OS cells with two separate siRNA mixtures against USP1 and found that USP1 depletion significantly decreased TAZ protein levels in OS cells (Fig. 2A), whereas no significant change was observed at mRNA levels according to qRT-PCR (Fig. 2B)."
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"In addition, USP1 overexpression elevated the TAZ protein level (Figs."
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"The immunoblot data showed that USP1 knockdown decreased the protein level of TAZ, which could be reversed by further TAZ overexpression (Fig. 4A)."
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"USP1 depletion decreased the TAZ protein level in HLF cells, and MG132 treatment reversed the USP1 depletion-induced reduction in the TAZ protein level in HLF cells (Fig. 5F)."
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"According to these data, we proposed that USP1 modulates the protein level of TAZ via the proteasomal degradation system."
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