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Statements

Prostaglandin E2 inhibits IFNB1. 3 / 3
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"PGE 2 suppresses IFN-beta induction and boosts IL-10 release by costimulated macrophages."
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"We found that PGE2 could inhibit the differentiation of MDSCs and PMN-MDSCs (Fig.  xref c) and IFN-β could inhibit the differentiation of M-MDSCs significantly (Fig.  xref d)."
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"Treating mice with prostaglandin E2 and zileuton, which limit IFNbeta induction, confers tolerance to Mtb [XREF_BIBR] and zileuton has been developed as a drug that can be administered to TB patients to enhance the efficacy of antibiotic treatment [XREF_BIBR]."
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