IndraLab

Statements

CYLD activates Death. 7 / 7
| 7
reach
"Indeed, our results demonstrate that upregulation of CYLD in cardiomyocytes impairs autophagy at the stage of autolysosome efflux and enhances myocardial death in PO-hearts."
32553594
reach
"Overexpression of CYLD promoted more apoptotic death ratio in PC-9/GR cells than that in PC-9 cells."
32441799
reach
"IKK blockade reactivates CYLD, as evidenced by the reduction in RIPK1 ubiquitination, which leads to the association of RIPK1 with the death-inducing signaling complex (DISC) to trigger cell death."
32024820
reach
"CYLD inactivates mechanistic target of rapamycin complex 1 (mTORC1) reactivation, upregulates Ras genes from rat brain 7 (Rab7) and enhances cardiomyocyte death in pressure overloaded hearts.."
32553594
reach
"Following the TNFR1 mediated assembly of pro inflammatory complex I, deubiquitinases (CYLD or A20) remove polyubiquitin chains from RIPK1 to terminate inflammation and enable downstream death signaling [50,51]."
| PMC
reach
"In addition, Cyld gene gain- and/or loss-of-function approaches in vitro and in vivo demonstrated that CYLD mediated cardiomyocyte death associated with impaired reactivation of mechanistic target of rapamycin complex 1 (mTORC1) and upregulated Ras genes from rat brain 7 (Rab7), two key components for autolysosomal degradation."
32553594
reach
"Nonetheless, it is possible for death-signaling CYLD and RIPK1 molecules, activated by disruption of the early checkpoint, to override the protection provided by the second NFκB-dependent checkpoint."
32024820