IndraLab

Statements

USP13 ubiquitinates UIMC1. 3 / 3
| 3
reach
"We found that mutating the 3 sites (K75, K90 and K112, 3KR) near or at the UIM domains, but not the other sites, abolished USP13 deficiency induced RAP80 ubiquitination (XREF_FIG and XREF_SUPPLEMENTARY)."
28569838
reach
"As shown in XREF_FIG, USP13 deficiency dramatically elevated the ubiquitination of RAP80 in vivo."
28569838
reach
"Taken together, USP13 has an impact on ubiquitination of RAP80, instead of its protein degradation, to regulate its focus formation and DDR-related function."
35445009