IndraLab

Statements

(E)-cinnamaldehyde inhibits NLRP3. 8 / 8
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"Cinnamaldehyde suppresses NLRP3 derived IL-1beta via activating succinate and HIF -1 in rheumatoid arthritis rats."
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"Another potential hypothesis to explain cinnamaldehyde-mediated NLRP3 inhibition involves the induction of autophagy."
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"In this study, cinnamaldehyde and allopurinol inhibited NLRP3 inflammasome activation to reduce IL-1beta release and TGF-beta and Smads signaling in animal and cell models."
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"Cinnamaldehyde inhibits the NLRP3 inflammasome in the treatment of sepsis [44] ."
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"In another study, cinnamaldehyde repressed NLRP3-associated IL-1β generation via activating succinate/HIF-1 in rheumatoid arthritis rats, thus providing a potential therapeutic substance to cease rheu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Liu et al. (2024) also obtained similar results, further supporting the hypothesis that cinnamaldehyde inhibits NLRP3 inflammasome activity, at least partially, through autophagy induction [67]."
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"Conversely, cinnamaldehyde, a common E-liquid flavouring, reduced the 100 expression of the NLRP3 inflammasome in mice exposed to endotoxin (Xu et al., 101 2017)."
| DOI
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"Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages."
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