IndraLab

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USP12 activates WDR48. 3 / 3
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"It raises the possibility that a targeted knockout of Uaf1 in granulosa cells might lead to infertility in female mice, which could provide further insights into UAF1’s specific functions in female reproductive biology.UAF1 acts as a cofactor for USP1, USP12, and USP46, enhancing their deubiquitinase activity by forming stable UAF1/USP protein complexes.14 18 Defective spermiogenesis in Uaf1 sKO mice necessitated the identification of a DUB critical for this process."
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"USP12 activates UAF1 at the biochemical level, causing the deubiquitination of Notch in cells and in vitro."
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"These results indicated that UAF1 suppressed JEV replication.As the cofactor of USP1, USP12, and USP46, UAF1 could enhance their deubiquitinase activity by forming stable UAF1/USP protein complexes (6, 38)."
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