IndraLab

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USP48 deubiquitinates SIRT6. 4 / 4
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"The deubiquitination of SIRT6 by USP10 and USP48 inhibits cancer formation by preventing the growth and development of cancer cells."
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"<span class="match term0">USP48</span> physically bound and stabilized <span class="match term1">SIRT6</span> by K48-linked deubiquitination at the K33 and K128 sites of <span class="match term1">SIRT6</span>, which impeded metabolic reprogramming to hamper HCC tumorigenesis"
33903120
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"The elevated USP48 further repress the ubiquitination of sirtuins 6 (SIRT6), therefore mitigating aerobic glycolysis and hindering tumor metastasis in HCC [89]."
38293446
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"METTL14-triggered m6A methylation also inhibits the degradation of ubiquitin specific peptidase 48 (USP48) mRNA, which can deubiquitylate and stabilize sirtuin 6 (SIRT6) to suppresses glycolysis and HCC tumorigenesis."
35974338