IndraLab

Statements

USP48 deubiquitinates SIRT6. 3 / 4
1 | 3
reach
"The deubiquitination of SIRT6 by USP10 and USP48 inhibits cancer formation by preventing the growth and development of cancer cells."
37175631
reach
"The elevated USP48 further repress the ubiquitination of sirtuins 6 (SIRT6), therefore mitigating aerobic glycolysis and hindering tumor metastasis in HCC [89]."
38293446
reach
"METTL14-triggered m6A methylation also inhibits the degradation of ubiquitin specific peptidase 48 (USP48) mRNA, which can deubiquitylate and stabilize sirtuin 6 (SIRT6) to suppresses glycolysis and HCC tumorigenesis."
35974338