IndraLab

Statements

COPS6 activates TP53. 2 / 2
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"Since 14-3-3sigma is regulated by p53, at issue is whether CSN6 mediated 14-3-3sigma downregulation involves p53."
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"Noticeably, reduced expression of Csn6 in Emicro-Myc background can also contribute to p53 stabilization in 33% of Emicro-Myc and Csn6 +/- lymphomas when compared with Emicro-Myc and Csn6 +/+, suggesting that both CSN6 mediated p53 downregulation and CSN6 mediated Myc elevation contribute to lymphomagenesis of this system (XREF_FIG)."
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