IndraLab

Statements

USP7 decreases the amount of NLRP3. 4 / 4
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"Moreover, the NLRP3 expression and ASC speck formation were reduced by downregulation of USP7, which improved the growth of OS cells as well."
38467635
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"We evaluated the K48-and K63-ubiquitin levels of NLRP3 following downregulation of USP7."
38467635
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"Thus, USP7 regulates NLRP3 inflammasome activation, and chemical inhibition of USP7 by P22077 promotes the ubiquitination level of NLRP3 and blocks inflammasome activation, indicating the multiple roles of USP7."
33584299
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"These results suggest that downregulation of USP7 increased K48-ubiquitination of NLRP3, thereby decreasing the expression of NLRP3."
38467635